The relative bioavailability of hydrocodone from hydrocodone bitartrate and acetaminophen tablets compared to extended-release hydrocodone products is unknown, so conversion to extended-release products must be accompanied by close observation for signs of excessive sedation and respiratory depression. Conversion From Hydrocodone Bitartrate And Acetaminophen Tablets To Extended-Release Hydrocodone It is safer to underestimate a patient’s 24-hour hydrocodone bitartrate and acetaminophen tablets dosage than to overestimate the 24-hour hydrocodone bitartrate and acetaminophen tablets dosage and manage an adverse reaction due to overdose. Therefore, a conservative approach is advised when determining the total daily dosage of hydrocodone bitartrate and acetaminophen tablets. There is inter-patient variability in the potency of opioid drugs and opioid formulations. The total daily dosage should not exceed 6 tablets.Ĭonversion From Other Opioids To Hydrocodone Bitartrate And Acetaminophen Tablets The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 8 tablets. ![]() The usual adult dosage is one or two tablets every four to six hours as needed for Initial Dosage Initiating Treatment With Hydrocodone Bitartrate And Acetaminophen Tablets Initiate the dosing regimen for each patient individually, taking into account the patient’s severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse.įollow patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with hydrocodone bitartrate and acetaminophen tablets and adjust the dosage accordingly. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. ![]() Important Dosage And Administration Instructions
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